Drug interactions
Leniolisib + Magnesium
Severity: Moderate
Leniolisib and Magnesium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium-containing antacids raise gastric pH and may reduce leniolisib dissolution and absorption, lessening its effect.
What this interaction means in plain words
Leniolisib and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Magnesium belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH reduces the pH-dependent solubility of leniolisib.
What to do
Separate leniolisib from magnesium antacids by at least 2 hours before or after.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leniolisib
Other interactions of Magnesium
- Ciprofloxacin + Magnesium Major
- Magnesium + Pancuronium Major
- Magnesium + Rocuronium Major
- Magnesium + Vecuronium Major
- Amikacin + Magnesium Moderate
- Amphotericin b deoxycholate + Magnesium Moderate
Frequently asked questions
Can I take Leniolisib with Magnesium?
MediHelp rates the interaction as moderate. Leniolisib and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium-containing antacids raise gastric pH and may reduce leniolisib dissolution and absorption, lessening its effect.
How serious is the interaction between Leniolisib and Magnesium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate leniolisib from magnesium antacids by at least 2 hours before or after.
What other medicines interact with Leniolisib?
MediHelp also lists interactions of Leniolisib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Leniolisib page.
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