Drug interactions
Leniolisib + Mexiletine
Severity: Moderate
Leniolisib and Mexiletine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib is a weak CYP1A2 inhibitor in labeling, and mexiletine is a narrow therapeutic index CYP1A2 substrate. Mexiletine exposure may rise, with possible tremor, dizziness, nausea and arrhythmia.
What this interaction means in plain words
Leniolisib and Mexiletine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Mexiletine belongs to Cardiovascular.
Why it happens
Leniolisib inhibits CYP1A2-mediated mexiletine metabolism.
What to do
Monitor for signs of mexiletine toxicity and reduce its dose if they appear; consider ECG monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Mexiletine?
MediHelp rates the interaction as moderate. Leniolisib and Mexiletine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib is a weak CYP1A2 inhibitor in labeling, and mexiletine is a narrow therapeutic index CYP1A2 substrate. Mexiletine exposure may rise, with possible tremor, dizziness, nausea and arrhythmia.
How serious is the interaction between Leniolisib and Mexiletine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of mexiletine toxicity and reduce its dose if they appear; consider ECG monitoring.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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