Drug interactions
Leniolisib + Mifepristone
Severity: Moderate
Leniolisib and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may increase leniolisib exposure by inhibiting its CYP3A4 metabolism. Increased exposure could raise the risk of leniolisib adverse effects.
What this interaction means in plain words
Leniolisib and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated metabolism of leniolisib by mifepristone.
What to do
Avoid concurrent use if an alternative is available. If used together, monitor for leniolisib adverse effects and review the need for dose adjustment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Mifepristone?
MediHelp rates the interaction as moderate. Leniolisib and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone may increase leniolisib exposure by inhibiting its CYP3A4 metabolism. Increased exposure could raise the risk of leniolisib adverse effects.
How serious is the interaction between Leniolisib and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if an alternative is available. If used together, monitor for leniolisib adverse effects and review the need for dose adjustment.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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