Drug interactions
Leniolisib + Paclitaxel
Severity: Moderate
Leniolisib and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits OATP1B1 and OATP1B3 and may increase paclitaxel exposure by reducing hepatic uptake. This could worsen myelosuppression and neuropathy.
What this interaction means in plain words
Leniolisib and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Paclitaxel belongs to Oncology.
Why it happens
Inhibition of OATP1B1/1B3-mediated hepatic uptake of paclitaxel.
What to do
Monitor blood counts and neuropathy during co-treatment, and reduce the paclitaxel dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Paclitaxel?
MediHelp rates the interaction as moderate. Leniolisib and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits OATP1B1 and OATP1B3 and may increase paclitaxel exposure by reducing hepatic uptake. This could worsen myelosuppression and neuropathy.
How serious is the interaction between Leniolisib and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy during co-treatment, and reduce the paclitaxel dose if toxicity develops.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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