Drug interactions
Leniolisib + Ramelteon
Severity: Moderate
Leniolisib and Ramelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib is a weak CYP1A2 inhibitor and may raise exposure to CYP1A2 substrates such as ramelteon. Higher ramelteon concentrations could lead to increased drowsiness and dizziness. The effect is expected to be modest.
What this interaction means in plain words
Leniolisib and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Ramelteon belongs to Central Nervous System.
Why it happens
Leniolisib inhibits CYP1A2, decreasing ramelteon clearance.
What to do
Monitor for increased sedation and consider a lower ramelteon dose if effects are excessive. Use an alternative hypnotic if problems persist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Ramelteon?
MediHelp rates the interaction as moderate. Leniolisib and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib is a weak CYP1A2 inhibitor and may raise exposure to CYP1A2 substrates such as ramelteon. Higher ramelteon concentrations could lead to increased drowsiness and dizziness. The effect is expected to be modest.
How serious is the interaction between Leniolisib and Ramelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and consider a lower ramelteon dose if effects are excessive. Use an alternative hypnotic if problems persist.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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