Drug interactions
Leniolisib + Simvastatin
Severity: Moderate
Leniolisib and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP, OATP1B1 and OATP1B3, transporters involved in simvastatin disposition. Exposure may increase and raise the risk of myopathy.
What this interaction means in plain words
Leniolisib and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Simvastatin belongs to Cardiovascular.
Why it happens
Leniolisib inhibits hepatic OATP uptake and BCRP efflux, increasing simvastatin levels.
What to do
Use the lowest effective simvastatin dose and monitor for muscle symptoms, checking CK if they occur. Consider a statin with lower transporter dependence.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Simvastatin?
MediHelp rates the interaction as moderate. Leniolisib and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits BCRP, OATP1B1 and OATP1B3, transporters involved in simvastatin disposition. Exposure may increase and raise the risk of myopathy.
How serious is the interaction between Leniolisib and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective simvastatin dose and monitor for muscle symptoms, checking CK if they occur. Consider a statin with lower transporter dependence.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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