Drug interactions
Lenvatinib + Olanzapine
Severity: Moderate
Lenvatinib and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenvatinib can prolong the QT interval, and olanzapine may contribute a small additional effect. The combination may increase the risk of serious arrhythmia.
What this interaction means in plain words
Lenvatinib and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenvatinib belongs to Oncology; Olanzapine belongs to Central Nervous System.
Why it happens
Additive prolongation of the QT interval.
What to do
Monitor ECG and keep potassium, magnesium and calcium within normal ranges. Consider an alternative antipsychotic if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Lenvatinib with Olanzapine?
MediHelp rates the interaction as moderate. Lenvatinib and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenvatinib can prolong the QT interval, and olanzapine may contribute a small additional effect. The combination may increase the risk of serious arrhythmia.
How serious is the interaction between Lenvatinib and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and keep potassium, magnesium and calcium within normal ranges. Consider an alternative antipsychotic if the QTc becomes prolonged.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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