Drug interactions
Lesinurad + Nicardipine
Severity: Minor
Lesinurad and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine can inhibit CYP2C9 in vitro and may modestly raise lesinurad levels. Clinical relevance is unproven.
What this interaction means in plain words
Lesinurad and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lesinurad belongs to Genitourinary; Nicardipine belongs to Cardiovascular.
Why it happens
Nicardipine inhibits CYP2C9, potentially reducing lesinurad metabolism.
What to do
Monitor renal function periodically. No dose adjustment is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Other interactions of Nicardipine
Frequently asked questions
Can I take Lesinurad with Nicardipine?
MediHelp rates the interaction as minor. Lesinurad and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine can inhibit CYP2C9 in vitro and may modestly raise lesinurad levels. Clinical relevance is unproven.
How serious is the interaction between Lesinurad and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function periodically. No dose adjustment is usually needed.
What other medicines interact with Lesinurad?
MediHelp also lists interactions of Lesinurad with, for example, Norethisterone, Acetylsalicylic acid, Amiodarone. The full list is on the Lesinurad page.
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