Drug interactions
Lesinurad + Rifapentine
Severity: Minor
Lesinurad and Rifapentine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces hepatic enzymes and may lower lesinurad concentrations. This could reduce its efficacy.
What this interaction means in plain words
Lesinurad and Rifapentine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lesinurad belongs to Genitourinary; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces CYP2C9, increasing lesinurad metabolism.
What to do
Monitor serum uric acid and gout control while on rifapentine. Adjust the urate-lowering regimen if response is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Lesinurad with Rifapentine?
MediHelp rates the interaction as minor. Lesinurad and Rifapentine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifapentine induces hepatic enzymes and may lower lesinurad concentrations. This could reduce its efficacy.
How serious is the interaction between Lesinurad and Rifapentine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout control while on rifapentine. Adjust the urate-lowering regimen if response is lost.
What other medicines interact with Lesinurad?
MediHelp also lists interactions of Lesinurad with, for example, Norethisterone, Acetylsalicylic acid, Amiodarone. The full list is on the Lesinurad page.
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