Drug interactions
Lesinurad + Tolbutamide
Severity: Minor
Lesinurad and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are CYP2C9 substrates, so competition could slightly raise lesinurad levels. Lesinurad is a weak CYP3A inducer and not a significant CYP2C9 inhibitor, so any effect is small.
What this interaction means in plain words
Lesinurad and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lesinurad belongs to Genitourinary; Tolbutamide belongs to Endocrine.
Why it happens
Possible competition for CYP2C9 metabolism; not an established interaction.
What to do
No dose adjustment is normally needed. Monitor blood glucose and renal function as routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Lesinurad with Tolbutamide?
MediHelp rates the interaction as minor. Lesinurad and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are CYP2C9 substrates, so competition could slightly raise lesinurad levels. Lesinurad is a weak CYP3A inducer and not a significant CYP2C9 inhibitor, so any effect is small.
How serious is the interaction between Lesinurad and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is normally needed. Monitor blood glucose and renal function as routine.
What other medicines interact with Lesinurad?
MediHelp also lists interactions of Lesinurad with, for example, Norethisterone, Acetylsalicylic acid, Amiodarone. The full list is on the Lesinurad page.
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