Drug interactions
Lesinurad + Valproic acid
Severity: Moderate
Lesinurad and Valproic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lesinurad is partly metabolized via microsomal epoxide hydrolase, which valproic acid can inhibit. Lesinurad exposure may increase, raising the risk of renal adverse effects.
What this interaction means in plain words
Lesinurad and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lesinurad belongs to Genitourinary; Valproic acid belongs to Central Nervous System.
Why it happens
Valproic acid inhibits epoxide hydrolase, potentially reducing lesinurad metabolism.
What to do
Avoid the combination where an alternative exists; otherwise monitor serum creatinine and renal symptoms closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Frequently asked questions
Can I take Lesinurad with Valproic acid?
MediHelp rates the interaction as moderate. Lesinurad and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lesinurad is partly metabolized via microsomal epoxide hydrolase, which valproic acid can inhibit. Lesinurad exposure may increase, raising the risk of renal adverse effects.
How serious is the interaction between Lesinurad and Valproic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative exists; otherwise monitor serum creatinine and renal symptoms closely.
What other medicines interact with Lesinurad?
MediHelp also lists interactions of Lesinurad with, for example, Norethisterone, Acetylsalicylic acid, Amiodarone. The full list is on the Lesinurad page.
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