Drug interactions
Letermovir + Letrozole
Severity: Minor
Letermovir and Letrozole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir is a moderate CYP3A inhibitor and letrozole is metabolized in part by CYP3A4 and CYP2A6. Letrozole exposure may rise modestly, though the clinical significance is not well established.
What this interaction means in plain words
Letermovir and Letrozole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Letermovir belongs to Anti Virals; Letrozole belongs to Oncology.
Why it happens
Letermovir inhibition of CYP3A4 reduces part of the metabolic clearance of letrozole.
What to do
No routine dose change is needed. Watch for increased letrozole adverse effects such as hot flashes, arthralgia or fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Letrozole
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Letrozole?
MediHelp rates the interaction as minor. Letermovir and Letrozole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir is a moderate CYP3A inhibitor and letrozole is metabolized in part by CYP3A4 and CYP2A6. Letrozole exposure may rise modestly, though the clinical significance is not well established.
How serious is the interaction between Letermovir and Letrozole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for increased letrozole adverse effects such as hot flashes, arthralgia or fatigue.
What other medicines interact with Letrozole?
MediHelp also lists interactions of Letrozole with, for example, Desogestrel-ethinyl estradiol, Ethinyl estradiol-drospirenone, Ethinyl estradiol-levonorgestrel. The full list is on the Letrozole page.
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