Drug interactions
Letermovir + Lidocaine
Severity: Moderate
Letermovir and Lidocaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir is a moderate CYP3A inhibitor and may raise exposure to lidocaine, which is partly metabolized by CYP3A4. The increase is likely modest because CYP1A2 is the main pathway, but toxicity is possible with systemic dosing.
What this interaction means in plain words
Letermovir and Lidocaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Lidocaine belongs to Cardiovascular.
Why it happens
Letermovir inhibits CYP3A4, reducing the metabolism of lidocaine to its metabolite.
What to do
Monitor for signs of lidocaine toxicity, including dizziness, paresthesia, confusion and arrhythmia, when systemic or repeated doses are used. Consider a lower dose or infusion rate if toxicity signs appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Lidocaine?
MediHelp rates the interaction as moderate. Letermovir and Lidocaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir is a moderate CYP3A inhibitor and may raise exposure to lidocaine, which is partly metabolized by CYP3A4. The increase is likely modest because CYP1A2 is the main pathway, but toxicity is possible with systemic dosing.
How serious is the interaction between Letermovir and Lidocaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of lidocaine toxicity, including dizziness, paresthesia, confusion and arrhythmia, when systemic or repeated doses are used. Consider a lower dose or infusion rate if toxicity signs appear.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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