Drug interactions
Letermovir + Metformin-pioglitazone
Severity: Moderate
Letermovir and Metformin-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP2C8 and OATP1B1/3, so it may raise pioglitazone exposure, which is metabolized by CYP2C8. This can increase pioglitazone effects such as edema and hypoglycemia when combined with other agents.
What this interaction means in plain words
Letermovir and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Letermovir inhibition of CYP2C8 and hepatic OATP transporters reduces pioglitazone clearance.
What to do
Monitor blood glucose and for fluid retention during coadministration, and reduce the pioglitazone dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Metformin-pioglitazone?
MediHelp rates the interaction as moderate. Letermovir and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits CYP2C8 and OATP1B1/3, so it may raise pioglitazone exposure, which is metabolized by CYP2C8. This can increase pioglitazone effects such as edema and hypoglycemia when combined with other agents.
How serious is the interaction between Letermovir and Metformin-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and for fluid retention during coadministration, and reduce the pioglitazone dose if needed.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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