Drug interactions
Letermovir + Oxcarbazepine
Severity: Moderate
Letermovir and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may reduce letermovir exposure, risking inadequate CMV prophylaxis. The magnitude is not well characterized for oxcarbazepine specifically. Letermovir labeling cautions against inducers.
What this interaction means in plain words
Letermovir and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Probable induction of UGT and other metabolic pathways; the exact mechanism is not firmly established.
What to do
Consider a non-inducing anticonvulsant, and monitor for CMV reactivation with PCR if combined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Oxcarbazepine?
MediHelp rates the interaction as moderate. Letermovir and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may reduce letermovir exposure, risking inadequate CMV prophylaxis. The magnitude is not well characterized for oxcarbazepine specifically. Letermovir labeling cautions against inducers.
How serious is the interaction between Letermovir and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-inducing anticonvulsant, and monitor for CMV reactivation with PCR if combined.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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