Drug interactions
Letermovir + Pantoprazole
Severity: Minor
Letermovir and Pantoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir induces CYP2C19 and may lower exposure to voriconazole and other CYP2C19 substrates such as pantoprazole. Reduced PPI exposure could weaken acid suppression.
What this interaction means in plain words
Letermovir and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Letermovir belongs to Anti Virals; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Letermovir induction of CYP2C19 increases pantoprazole metabolism, while CYP3A4 inhibition has a smaller effect.
What to do
Monitor for loss of acid control and increase the pantoprazole dose if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Pantoprazole?
MediHelp rates the interaction as minor. Letermovir and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir induces CYP2C19 and may lower exposure to voriconazole and other CYP2C19 substrates such as pantoprazole. Reduced PPI exposure could weaken acid suppression.
How serious is the interaction between Letermovir and Pantoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of acid control and increase the pantoprazole dose if symptoms occur.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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