Drug interactions
Letermovir + Pazopanib
Severity: Moderate
Letermovir and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib inhibits OATP1B1/3 in vitro, which could increase letermovir concentrations. Letermovir also inhibits CYP3A and may raise pazopanib exposure.
What this interaction means in plain words
Letermovir and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Pazopanib belongs to Oncology.
Why it happens
OATP1B1/3 inhibition by pazopanib reduces letermovir hepatic uptake, and letermovir inhibits CYP3A4.
What to do
Monitor for letermovir adverse effects and for pazopanib toxicity including liver enzymes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Pazopanib?
MediHelp rates the interaction as moderate. Letermovir and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib inhibits OATP1B1/3 in vitro, which could increase letermovir concentrations. Letermovir also inhibits CYP3A and may raise pazopanib exposure.
How serious is the interaction between Letermovir and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for letermovir adverse effects and for pazopanib toxicity including liver enzymes.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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