Drug interactions
Letermovir + Pioglitazone
Severity: Moderate
Letermovir and Pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP2C8 and OATP1B1/3, so it may raise pioglitazone exposure, which is mainly cleared by CYP2C8. This could increase glucose lowering, edema and hypoglycemia risk.
What this interaction means in plain words
Letermovir and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Pioglitazone belongs to Endocrine.
Why it happens
Letermovir inhibits CYP2C8, reducing pioglitazone metabolism.
What to do
Monitor blood glucose and for edema while the two are combined, and reduce the pioglitazone dose if hypoglycemia or fluid retention occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Letermovir and Pioglitazone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Pioglitazone
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Pioglitazone?
MediHelp rates the interaction as moderate. Letermovir and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits CYP2C8 and OATP1B1/3, so it may raise pioglitazone exposure, which is mainly cleared by CYP2C8. This could increase glucose lowering, edema and hypoglycemia risk.
How serious is the interaction between Letermovir and Pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and for edema while the two are combined, and reduce the pioglitazone dose if hypoglycemia or fluid retention occurs.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
