Drug interactions
Letermovir + Salmeterol
Severity: Moderate
Letermovir and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir is a moderate CYP3A inhibitor and may increase salmeterol exposure. This can raise the risk of tachycardia, tremor, hypokalemia and QT prolongation.
What this interaction means in plain words
Letermovir and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Salmeterol belongs to Respiratory.
Why it happens
Letermovir inhibits CYP3A4-mediated metabolism of salmeterol.
What to do
Monitor heart rate, ECG and potassium in patients with cardiac risk factors. Consider a short-acting bronchodilator alternative if cardiovascular effects arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Salmeterol?
MediHelp rates the interaction as moderate. Letermovir and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir is a moderate CYP3A inhibitor and may increase salmeterol exposure. This can raise the risk of tachycardia, tremor, hypokalemia and QT prolongation.
How serious is the interaction between Letermovir and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and potassium in patients with cardiac risk factors. Consider a short-acting bronchodilator alternative if cardiovascular effects arise.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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