Drug interactions
Letermovir + Sorafenib
Severity: Minor
Letermovir and Sorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir moderately inhibits CYP3A4 and may raise sorafenib levels. Increased exposure could worsen sorafenib adverse effects.
What this interaction means in plain words
Letermovir and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Letermovir belongs to Anti Virals; Sorafenib belongs to Oncology.
Why it happens
Letermovir inhibits CYP3A4, reducing sorafenib metabolism.
What to do
Monitor for sorafenib toxicity such as diarrhea, hypertension and hand-foot skin reaction. Reduce the sorafenib dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sorafenib
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Sorafenib?
MediHelp rates the interaction as minor. Letermovir and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir moderately inhibits CYP3A4 and may raise sorafenib levels. Increased exposure could worsen sorafenib adverse effects.
How serious is the interaction between Letermovir and Sorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sorafenib toxicity such as diarrhea, hypertension and hand-foot skin reaction. Reduce the sorafenib dose if adverse effects occur.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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