Drug interactions
Letermovir + Tadalafil
Severity: Moderate
Letermovir and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir is a moderate CYP3A inhibitor and may increase tadalafil exposure, raising the risk of hypotension, headache, and priapism.
What this interaction means in plain words
Letermovir and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Tadalafil belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4 by letermovir reduces tadalafil metabolism.
What to do
Consider a reduced tadalafil dose and monitor blood pressure and adverse effects during letermovir therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Tadalafil?
MediHelp rates the interaction as moderate. Letermovir and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir is a moderate CYP3A inhibitor and may increase tadalafil exposure, raising the risk of hypotension, headache, and priapism.
How serious is the interaction between Letermovir and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a reduced tadalafil dose and monitor blood pressure and adverse effects during letermovir therapy.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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