Drug interactions
Letermovir + Valsartan
Severity: Moderate
Letermovir and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits OATP1B1/3 and may raise concentrations of valsartan, which is an OATP1B1 substrate. The result could be greater blood pressure lowering or exposure-related adverse effects, though the magnitude is not well defined.
What this interaction means in plain words
Letermovir and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Valsartan belongs to Cardiovascular.
Why it happens
Letermovir inhibition of OATP1B1/3 hepatic uptake may increase valsartan plasma concentrations.
What to do
Monitor blood pressure and renal function and potassium when letermovir is started or stopped. Reduce valsartan dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Valsartan?
MediHelp rates the interaction as moderate. Letermovir and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits OATP1B1/3 and may raise concentrations of valsartan, which is an OATP1B1 substrate. The result could be greater blood pressure lowering or exposure-related adverse effects, though the magnitude is not well defined.
How serious is the interaction between Letermovir and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function and potassium when letermovir is started or stopped. Reduce valsartan dose if hypotension occurs.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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