Drug interactions
Levamlodipine + Metronidazole
Severity: Minor
Levamlodipine and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole may modestly increase levamlodipine exposure by inhibiting CYP3A4. This could cause hypotension, peripheral edema and dizziness.
What this interaction means in plain words
Levamlodipine and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levamlodipine belongs to Cardiovascular; Metronidazole belongs to Anti Parasitic.
Why it happens
CYP3A4 inhibition by metronidazole reduces levamlodipine metabolism.
What to do
Monitor blood pressure and edema during co-therapy. Reduce the levamlodipine dose if hypotension or edema develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
Frequently asked questions
Can I take Levamlodipine with Metronidazole?
MediHelp rates the interaction as minor. Levamlodipine and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole may modestly increase levamlodipine exposure by inhibiting CYP3A4. This could cause hypotension, peripheral edema and dizziness.
How serious is the interaction between Levamlodipine and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema during co-therapy. Reduce the levamlodipine dose if hypotension or edema develops.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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