Drug interactions
Levamlodipine + Sildenafil
Severity: Minor
Levamlodipine and Sildenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levamlodipine is a calcium channel blocker, and sildenafil adds vasodilation, so blood pressure may fall further when used together. Studies with amlodipine showed additional but generally modest reductions in blood pressure.
What this interaction means in plain words
Levamlodipine and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levamlodipine belongs to Cardiovascular; Sildenafil belongs to Genitourinary.
Why it happens
Additive vasodilation through calcium channel blockade and PDE5 inhibition.
What to do
Monitor blood pressure and counsel on dizziness when starting sildenafil in patients on levamlodipine. Start with the lowest dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
Frequently asked questions
Can I take Levamlodipine with Sildenafil?
MediHelp rates the interaction as minor. Levamlodipine and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levamlodipine is a calcium channel blocker, and sildenafil adds vasodilation, so blood pressure may fall further when used together. Studies with amlodipine showed additional but generally modest reductions in blood pressure.
How serious is the interaction between Levamlodipine and Sildenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and counsel on dizziness when starting sildenafil in patients on levamlodipine. Start with the lowest dose.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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