Drug interactions
Levetiracetam + Loxapine
Severity: Moderate
Levetiracetam and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence, dizziness and fatigue, so combined use may worsen drowsiness and impair alertness. Loxapine also lowers the seizure threshold, which may work against the anticonvulsant effect of levetiracetam. Levetiracetam can also cause behavioral changes that could complicate psychiatric treatment.
What this interaction means in plain words
Levetiracetam and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Loxapine belongs to Central Nervous System.
Why it happens
Additive CNS depression, and a pharmacodynamic opposition between loxapine's proconvulsant effect and levetiracetam's antiseizure effect.
What to do
Monitor for sedation, seizure control and mood or behavioral changes. Use the lowest effective loxapine dose in patients with epilepsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Loxapine?
MediHelp rates the interaction as moderate. Levetiracetam and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence, dizziness and fatigue, so combined use may worsen drowsiness and impair alertness. Loxapine also lowers the seizure threshold, which may work against the anticonvulsant effect of levetiracetam. Levetiracetam can also cause behavioral changes that could complicate psychiatric treatment.
How serious is the interaction between Levetiracetam and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, seizure control and mood or behavioral changes. Use the lowest effective loxapine dose in patients with epilepsy.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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