Drug interactions
Levetiracetam + Maprotiline
Severity: Moderate
Levetiracetam and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence and dizziness, so together they may increase drowsiness and impair concentration. Maprotiline lowers the seizure threshold, which can counteract the antiseizure effect of levetiracetam in patients with epilepsy. Levetiracetam can also cause mood and behavioral changes that may complicate depression treatment.
What this interaction means in plain words
Levetiracetam and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression, with pharmacodynamic opposition of seizure threshold effects.
What to do
Monitor seizure control and sedation, and use caution with maprotiline in patients with epilepsy, using an antidepressant with lower seizure risk if possible. Counsel on driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Maprotiline?
MediHelp rates the interaction as moderate. Levetiracetam and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence and dizziness, so together they may increase drowsiness and impair concentration. Maprotiline lowers the seizure threshold, which can counteract the antiseizure effect of levetiracetam in patients with epilepsy. Levetiracetam can also cause mood and behavioral changes that may complicate depression treatment.
How serious is the interaction between Levetiracetam and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and sedation, and use caution with maprotiline in patients with epilepsy, using an antidepressant with lower seizure risk if possible. Counsel on driving.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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