Drug interactions
Levetiracetam + Metaxalone
Severity: Moderate
Levetiracetam and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levetiracetam commonly causes somnolence, dizziness and fatigue, which may be increased by metaxalone. Coordination and alertness may be impaired.
What this interaction means in plain words
Levetiracetam and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression.
What to do
Monitor for drowsiness and dizziness, especially early in therapy or after dose increases. Counsel the patient on driving and machinery use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Metaxalone?
MediHelp rates the interaction as moderate. Levetiracetam and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levetiracetam commonly causes somnolence, dizziness and fatigue, which may be increased by metaxalone. Coordination and alertness may be impaired.
How serious is the interaction between Levetiracetam and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and dizziness, especially early in therapy or after dose increases. Counsel the patient on driving and machinery use.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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