Drug interactions
Levetiracetam + Methohexital
Severity: Moderate
Levetiracetam and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a short-acting barbiturate anesthetic that causes dose-dependent CNS and respiratory depression. Levetiracetam may add to sedation, so the depth and duration of CNS depression can be greater than expected.
What this interaction means in plain words
Levetiracetam and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depression; methohexital enhances GABA-A activity while levetiracetam has sedative effects.
What to do
Titrate methohexital carefully to effect and monitor ventilation and oxygenation continuously. Allow for extended recovery and observation after the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Other interactions of Methohexital
Frequently asked questions
Can I take Levetiracetam with Methohexital?
MediHelp rates the interaction as moderate. Levetiracetam and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a short-acting barbiturate anesthetic that causes dose-dependent CNS and respiratory depression. Levetiracetam may add to sedation, so the depth and duration of CNS depression can be greater than expected.
How serious is the interaction between Levetiracetam and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital carefully to effect and monitor ventilation and oxygenation continuously. Allow for extended recovery and observation after the procedure.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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