Drug interactions
Levetiracetam + Tetrabenazine
Severity: Moderate
Levetiracetam and Tetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetrabenazine commonly causes somnolence, fatigue and depression, and levetiracetam can also cause drowsiness and mood changes. The combination may increase sedation and may worsen depressive symptoms.
What this interaction means in plain words
Levetiracetam and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Tetrabenazine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression (pharmacodynamic).
What to do
Monitor for excessive sedation and for emerging depression or suicidality. Reduce the tetrabenazine dose if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Levetiracetam with Tetrabenazine?
MediHelp rates the interaction as moderate. Levetiracetam and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tetrabenazine commonly causes somnolence, fatigue and depression, and levetiracetam can also cause drowsiness and mood changes. The combination may increase sedation and may worsen depressive symptoms.
How serious is the interaction between Levetiracetam and Tetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and for emerging depression or suicidality. Reduce the tetrabenazine dose if sedation is troublesome.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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