Drug interactions
Levetiracetam + Thioridazine
Severity: Moderate
Levetiracetam and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence, dizziness and fatigue, so combined use may increase sedation and impair coordination. Thioridazine can lower the seizure threshold, which may reduce seizure control with levetiracetam. Levetiracetam may also cause behavioral effects that overlap with psychiatric symptoms.
What this interaction means in plain words
Levetiracetam and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Additive CNS depression; thioridazine lowers the seizure threshold.
What to do
Monitor for sedation, mood changes and breakthrough seizures. Advise caution with driving until the response is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Thioridazine?
MediHelp rates the interaction as moderate. Levetiracetam and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence, dizziness and fatigue, so combined use may increase sedation and impair coordination. Thioridazine can lower the seizure threshold, which may reduce seizure control with levetiracetam. Levetiracetam may also cause behavioral effects that overlap with psychiatric symptoms.
How serious is the interaction between Levetiracetam and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, mood changes and breakthrough seizures. Advise caution with driving until the response is established.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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