Drug interactions
Levetiracetam + Tolcapone
Severity: Moderate
Levetiracetam and Tolcapone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levetiracetam commonly causes somnolence, and tolcapone can cause dizziness, somnolence and sudden sleep episodes in patients with Parkinson disease. Using both could increase daytime sleepiness and impair alertness.
What this interaction means in plain words
Levetiracetam and Tolcapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Tolcapone belongs to Central Nervous System.
Why it happens
Additive CNS effects on alertness; no pharmacokinetic interaction is established.
What to do
Monitor for daytime sleepiness and dizziness and counsel patients on driving safety. Reassess therapy if sudden sleep episodes or marked sedation occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Other interactions of Tolcapone
- Isocarboxazid + Tolcapone Contraindicated
- Phenelzine + Tolcapone Contraindicated
- Tolcapone + Tranylcypromine Contraindicated
- Metoclopramide + Tolcapone Major
- Apomorphine + Tolcapone Moderate
- Asenapine + Tolcapone Moderate
Frequently asked questions
Can I take Levetiracetam with Tolcapone?
MediHelp rates the interaction as moderate. Levetiracetam and Tolcapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levetiracetam commonly causes somnolence, and tolcapone can cause dizziness, somnolence and sudden sleep episodes in patients with Parkinson disease. Using both could increase daytime sleepiness and impair alertness.
How serious is the interaction between Levetiracetam and Tolcapone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for daytime sleepiness and dizziness and counsel patients on driving safety. Reassess therapy if sudden sleep episodes or marked sedation occur.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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