Drug interactions
Levetiracetam + Ziprasidone
Severity: Minor
Levetiracetam and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence and dizziness, so taking them together may increase daytime sedation and impair psychomotor performance. The effect is usually modest and manageable.
What this interaction means in plain words
Levetiracetam and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levetiracetam belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects (pharmacodynamic).
What to do
Counsel the patient about drowsiness and caution with driving or machinery, especially at initiation or after dose increases. Reduce doses if excessive sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Ziprasidone?
MediHelp rates the interaction as minor. Levetiracetam and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause somnolence and dizziness, so taking them together may increase daytime sedation and impair psychomotor performance. The effect is usually modest and manageable.
How serious is the interaction between Levetiracetam and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about drowsiness and caution with driving or machinery, especially at initiation or after dose increases. Reduce doses if excessive sedation occurs.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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