Drug interactions
Levocetirizine + Tranylcypromine
Severity: Moderate
Levocetirizine and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can intensify and prolong the anticholinergic and sedative effects of antihistamines. Levocetirizine has little anticholinergic activity, but additive drowsiness remains possible.
What this interaction means in plain words
Levocetirizine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levocetirizine belongs to Respiratory; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression, with MAO inhibition possibly potentiating antihistamine anticholinergic effects.
What to do
Monitor for sedation, dizziness and anticholinergic effects. Advise against driving until the response is known and lower the levocetirizine dose if sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levocetirizine
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Levocetirizine with Tranylcypromine?
MediHelp rates the interaction as moderate. Levocetirizine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can intensify and prolong the anticholinergic and sedative effects of antihistamines. Levocetirizine has little anticholinergic activity, but additive drowsiness remains possible.
How serious is the interaction between Levocetirizine and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and anticholinergic effects. Advise against driving until the response is known and lower the levocetirizine dose if sedation occurs.
What other medicines interact with Levocetirizine?
MediHelp also lists interactions of Levocetirizine with, for example, Acrivastine, Asenapine transdermal, Avapritinib. The full list is on the Levocetirizine page.
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