Drug interactions
Levodopa + Nicardipine
Severity: Moderate
Levodopa and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension, and nicardipine lowers blood pressure through vasodilation. Together they may cause more frequent or severe dizziness, falls and syncope, especially at the start of therapy or after dose increases.
What this interaction means in plain words
Levodopa and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levodopa belongs to Central Nervous System; Nicardipine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects of dopamine-mediated vasodilation and calcium channel blockade.
What to do
Check sitting and standing blood pressure when starting or changing either drug. Lower the nicardipine dose if orthostatic symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Levodopa with Nicardipine?
MediHelp rates the interaction as moderate. Levodopa and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension, and nicardipine lowers blood pressure through vasodilation. Together they may cause more frequent or severe dizziness, falls and syncope, especially at the start of therapy or after dose increases.
How serious is the interaction between Levodopa and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check sitting and standing blood pressure when starting or changing either drug. Lower the nicardipine dose if orthostatic symptoms appear.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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