Drug interactions
Levofloxacin + Linagliptin-metformin
Severity: Moderate
Levofloxacin and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones such as levofloxacin can cause both hypoglycemia and hyperglycemia in patients with diabetes taking glucose-lowering drugs. Severe cases of hypoglycemia have been reported, particularly in older patients and those with renal impairment.
What this interaction means in plain words
Levofloxacin and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Linagliptin-metformin belongs to Endocrine.
Why it happens
Fluoroquinolones affect pancreatic beta-cell potassium channels, altering insulin release.
What to do
Monitor blood glucose closely during the antibiotic course and educate the patient on symptoms of dysglycemia. Stop the fluoroquinolone and treat if significant dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Levofloxacin and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones such as levofloxacin can cause both hypoglycemia and hyperglycemia in patients with diabetes taking glucose-lowering drugs. Severe cases of hypoglycemia have been reported, particularly in older patients and those with renal impairment.
How serious is the interaction between Levofloxacin and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during the antibiotic course and educate the patient on symptoms of dysglycemia. Stop the fluoroquinolone and treat if significant dysglycemia occurs.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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