Drug interactions
Levofloxacin + Memantine-donepezil
Severity: Moderate
Levofloxacin and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levofloxacin can prolong the QT interval and donepezil has QT-prolonging potential, so together they may raise the risk of torsades de pointes. Risk is greater with bradycardia, hypokalemia or advanced age.
What this interaction means in plain words
Levofloxacin and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Use an alternative antibiotic if reasonable. If combined, correct electrolytes and monitor the ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Memantine-donepezil?
MediHelp rates the interaction as moderate. Levofloxacin and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levofloxacin can prolong the QT interval and donepezil has QT-prolonging potential, so together they may raise the risk of torsades de pointes. Risk is greater with bradycardia, hypokalemia or advanced age.
How serious is the interaction between Levofloxacin and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic if reasonable. If combined, correct electrolytes and monitor the ECG.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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