Drug interactions
Levofloxacin + Oxaprozin
Severity: Moderate
Levofloxacin and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can lower the seizure threshold, and concurrent NSAID use may increase the risk of CNS stimulation or convulsions. The risk is greatest in patients with epilepsy, CNS lesions or renal impairment.
What this interaction means in plain words
Levofloxacin and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Oxaprozin belongs to Musculoskeletal.
Why it happens
Fluoroquinolone inhibition of GABA binding at GABA-A receptors may be potentiated by NSAIDs.
What to do
Avoid the combination in patients with seizure disorders or predisposing CNS conditions. Otherwise monitor for neurological symptoms and adjust levofloxacin dose in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Oxaprozin?
MediHelp rates the interaction as moderate. Levofloxacin and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can lower the seizure threshold, and concurrent NSAID use may increase the risk of CNS stimulation or convulsions. The risk is greatest in patients with epilepsy, CNS lesions or renal impairment.
How serious is the interaction between Levofloxacin and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with seizure disorders or predisposing CNS conditions. Otherwise monitor for neurological symptoms and adjust levofloxacin dose in renal impairment.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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