Drug interactions
Levofloxacin + Primaquine
Severity: Moderate
Levofloxacin and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primaquine has been associated with QT prolongation, and levofloxacin has similar effects. Combined use may increase the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Levofloxacin and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Primaquine belongs to Anti Parasitic.
Why it happens
Additive effects on cardiac repolarization.
What to do
Check a baseline ECG and electrolytes and monitor the QTc during co-administration. Consider an alternative antibiotic in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Frequently asked questions
Can I take Levofloxacin with Primaquine?
MediHelp rates the interaction as moderate. Levofloxacin and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primaquine has been associated with QT prolongation, and levofloxacin has similar effects. Combined use may increase the risk of serious ventricular arrhythmia.
How serious is the interaction between Levofloxacin and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and monitor the QTc during co-administration. Consider an alternative antibiotic in patients with QT risk factors.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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