Drug interactions
Levofloxacin + Repaglinide
Severity: Moderate
Levofloxacin and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause hypoglycemia or hyperglycemia in patients on insulin secretagogues. Repaglinide stimulates insulin release, so the risk of hypoglycemia may be raised.
What this interaction means in plain words
Levofloxacin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Repaglinide belongs to Endocrine.
Why it happens
Fluoroquinolones alter beta-cell insulin release, which may add to the secretagogue effect of repaglinide.
What to do
Monitor blood glucose closely during the antibiotic course and teach the patient about hypoglycemia. Reduce the repaglinide dose if low glucose occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Levofloxacin with Repaglinide?
MediHelp rates the interaction as moderate. Levofloxacin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause hypoglycemia or hyperglycemia in patients on insulin secretagogues. Repaglinide stimulates insulin release, so the risk of hypoglycemia may be raised.
How serious is the interaction between Levofloxacin and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during the antibiotic course and teach the patient about hypoglycemia. Reduce the repaglinide dose if low glucose occurs.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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