Drug interactions
Levofloxacin + Strontium ranelate
Severity: Moderate
Levofloxacin and Strontium ranelate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral strontium ranelate can bind levofloxacin in the gut and reduce its absorption, which may lead to subtherapeutic antibiotic concentrations and treatment failure. The effect is relevant only when both are taken by mouth.
What this interaction means in plain words
Levofloxacin and Strontium ranelate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Strontium ranelate belongs to Musculoskeletal.
Why it happens
Chelation of the fluoroquinolone by divalent strontium cations in the gastrointestinal tract, reducing absorption.
What to do
Interrupt strontium ranelate for the duration of oral levofloxacin therapy. If it cannot be stopped, separate doses widely and watch for clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Strontium ranelate
Frequently asked questions
Can I take Levofloxacin with Strontium ranelate?
MediHelp rates the interaction as moderate. Levofloxacin and Strontium ranelate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral strontium ranelate can bind levofloxacin in the gut and reduce its absorption, which may lead to subtherapeutic antibiotic concentrations and treatment failure. The effect is relevant only when both are taken by mouth.
How serious is the interaction between Levofloxacin and Strontium ranelate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Interrupt strontium ranelate for the duration of oral levofloxacin therapy. If it cannot be stopped, separate doses widely and watch for clinical response.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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