Drug interactions
Levofloxacin + Sulindac
Severity: Moderate
Levofloxacin and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can lower the seizure threshold, and concurrent NSAID use may increase CNS excitation in predisposed patients. Seizures are uncommon but serious.
What this interaction means in plain words
Levofloxacin and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Sulindac belongs to Musculoskeletal.
Why it happens
Fluoroquinolone inhibition of GABA binding at GABA-A receptors, potentially enhanced by NSAIDs.
What to do
Avoid the combination in patients with epilepsy, prior seizures or other CNS risk factors. Otherwise monitor for tremor, agitation or seizures and stop levofloxacin if they appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Sulindac?
MediHelp rates the interaction as moderate. Levofloxacin and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can lower the seizure threshold, and concurrent NSAID use may increase CNS excitation in predisposed patients. Seizures are uncommon but serious.
How serious is the interaction between Levofloxacin and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with epilepsy, prior seizures or other CNS risk factors. Otherwise monitor for tremor, agitation or seizures and stop levofloxacin if they appear.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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