Drug interactions
Levofloxacin + Tolfenamic acid
Severity: Moderate
Levofloxacin and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones lower the seizure threshold, and concurrent NSAID use may increase this effect. Seizures are uncommon but more likely in patients with epilepsy, prior CNS disease, renal impairment or older age.
What this interaction means in plain words
Levofloxacin and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Fluoroquinolones inhibit GABA-A receptor binding, and NSAIDs may potentiate this effect.
What to do
Avoid the combination in patients with seizure disorders or other seizure risk factors. If it is used, tell the patient to report tremor, confusion or twitching and stop levofloxacin if seizures occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Levofloxacin with Tolfenamic acid?
MediHelp rates the interaction as moderate. Levofloxacin and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones lower the seizure threshold, and concurrent NSAID use may increase this effect. Seizures are uncommon but more likely in patients with epilepsy, prior CNS disease, renal impairment or older age.
How serious is the interaction between Levofloxacin and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with seizure disorders or other seizure risk factors. If it is used, tell the patient to report tremor, confusion or twitching and stop levofloxacin if seizures occur.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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