Drug interactions
Levofloxacin + Trilaciclib
Severity: Moderate
Levofloxacin and Trilaciclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilaciclib inhibits renal transporters OCT2, MATE1 and MATE2-K, which may contribute to the renal secretion of levofloxacin. Levofloxacin exposure could rise, though the clinical effect is probably modest and levofloxacin has a fairly wide margin of safety.
What this interaction means in plain words
Levofloxacin and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Trilaciclib belongs to Oncology.
Why it happens
Inhibition of renal tubular secretion transporters (OCT2/MATE) by trilaciclib may reduce levofloxacin clearance.
What to do
Monitor for levofloxacin adverse effects such as QT prolongation, CNS effects and tendon symptoms, especially in renal impairment. Consider renal dose adjustment if function is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Trilaciclib
Frequently asked questions
Can I take Levofloxacin with Trilaciclib?
MediHelp rates the interaction as moderate. Levofloxacin and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trilaciclib inhibits renal transporters OCT2, MATE1 and MATE2-K, which may contribute to the renal secretion of levofloxacin. Levofloxacin exposure could rise, though the clinical effect is probably modest and levofloxacin has a fairly wide margin of safety.
How serious is the interaction between Levofloxacin and Trilaciclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for levofloxacin adverse effects such as QT prolongation, CNS effects and tendon symptoms, especially in renal impairment. Consider renal dose adjustment if function is reduced.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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