Drug interactions
Levofloxacin + Umeclidinium-vilanterol
Severity: Moderate
Levofloxacin and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levofloxacin can prolong the QT interval, and beta-2 agonists such as vilanterol may add to this effect through hypokalemia and adrenergic stimulation. Together they may increase the risk of ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Levofloxacin and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta-agonist-related hypokalemia and sympathetic stimulation.
What to do
Check potassium and magnesium and correct abnormalities. Consider ECG monitoring in patients with other QT risk factors, or choose a non-QT-prolonging antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Levofloxacin and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levofloxacin can prolong the QT interval, and beta-2 agonists such as vilanterol may add to this effect through hypokalemia and adrenergic stimulation. Together they may increase the risk of ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Levofloxacin and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and correct abnormalities. Consider ECG monitoring in patients with other QT risk factors, or choose a non-QT-prolonging antibiotic.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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