Drug interactions
Levoketoconazole + Pitavastatin
Severity: Moderate
Levoketoconazole and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole may inhibit OATP1B1 and so raise pitavastatin exposure. This could increase the risk of myopathy.
What this interaction means in plain words
Levoketoconazole and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Pitavastatin belongs to Cardiovascular.
Why it happens
Levoketoconazole may inhibit OATP1B1-mediated hepatic uptake of pitavastatin.
What to do
Use the lowest effective pitavastatin dose and monitor for muscle symptoms. Check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Pitavastatin?
MediHelp rates the interaction as moderate. Levoketoconazole and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole may inhibit OATP1B1 and so raise pitavastatin exposure. This could increase the risk of myopathy.
How serious is the interaction between Levoketoconazole and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective pitavastatin dose and monitor for muscle symptoms. Check CK if symptoms occur.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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