Drug interactions
Levoketoconazole + Rifaximin
Severity: Minor
Levoketoconazole and Rifaximin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole inhibits P-glycoprotein and may raise rifaximin absorption. The effect is probably small in most patients due to minimal rifaximin bioavailability.
What this interaction means in plain words
Levoketoconazole and Rifaximin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levoketoconazole belongs to Endocrine; Rifaximin belongs to Anti Bacterial.
Why it happens
P-glycoprotein inhibition reducing rifaximin efflux.
What to do
No dose change is normally needed. Monitor for rifaximin adverse effects in hepatic impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rifaximin
- Cholera vaccine + Rifaximin Major
- Microbiota + Rifaximin Major
- Amiodarone + Rifaximin Moderate
- Bcg intravesical live + Rifaximin Moderate
- Cyclosporine + Rifaximin Moderate
- Cyclosporin + Rifaximin Moderate
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Rifaximin?
MediHelp rates the interaction as minor. Levoketoconazole and Rifaximin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levoketoconazole inhibits P-glycoprotein and may raise rifaximin absorption. The effect is probably small in most patients due to minimal rifaximin bioavailability.
How serious is the interaction between Levoketoconazole and Rifaximin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed. Monitor for rifaximin adverse effects in hepatic impairment.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
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