Drug interactions
Levoketoconazole + Theophylline
Severity: Moderate
Levoketoconazole and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor, but theophylline relies on CYP3A4 only partly. A small to moderate rise in theophylline concentration is possible, which may be significant for a narrow-therapeutic-index drug.
What this interaction means in plain words
Levoketoconazole and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Theophylline belongs to Respiratory.
Why it happens
Levoketoconazole inhibits CYP3A4, a secondary pathway for theophylline clearance.
What to do
Monitor theophylline serum concentrations when starting or stopping levoketoconazole and lower the theophylline dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Theophylline?
MediHelp rates the interaction as moderate. Levoketoconazole and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor, but theophylline relies on CYP3A4 only partly. A small to moderate rise in theophylline concentration is possible, which may be significant for a narrow-therapeutic-index drug.
How serious is the interaction between Levoketoconazole and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline serum concentrations when starting or stopping levoketoconazole and lower the theophylline dose if levels rise.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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