Drug interactions
Levoketoconazole + Topiramate
Severity: Minor
Levoketoconazole and Topiramate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topiramate is a weak CYP3A4 inducer at higher doses and could slightly lower levoketoconazole exposure. The effect is expected to be small and is mostly theoretical. Reduced cortisol-lowering effect is the potential consequence.
What this interaction means in plain words
Levoketoconazole and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levoketoconazole belongs to Endocrine; Topiramate belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 by topiramate may modestly increase levoketoconazole metabolism.
What to do
No routine dose change is needed; monitor cortisol control if topiramate is started or stopped at high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Topiramate
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Topiramate?
MediHelp rates the interaction as minor. Levoketoconazole and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Topiramate is a weak CYP3A4 inducer at higher doses and could slightly lower levoketoconazole exposure. The effect is expected to be small and is mostly theoretical. Reduced cortisol-lowering effect is the potential consequence.
How serious is the interaction between Levoketoconazole and Topiramate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor cortisol control if topiramate is started or stopped at high doses.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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