Drug interactions
Levomilnacipran + Meclofenamic acid
Severity: Moderate
Levomilnacipran and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SNRIs reduce platelet serotonin uptake and impair platelet aggregation, and NSAIDs add antiplatelet effects and gastric mucosal injury. The combination raises the risk of bleeding, notably upper gastrointestinal bleeding.
What this interaction means in plain words
Levomilnacipran and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levomilnacipran belongs to Central Nervous System; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
Additive impairment of platelet function: depletion of platelet serotonin by SNRI plus NSAID COX-1 inhibition and mucosal injury.
What to do
Monitor for GI bleeding and bruising, and consider a proton pump inhibitor in higher-risk patients. Use the lowest NSAID dose for the shortest period or choose paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Meclofenamic acid?
MediHelp rates the interaction as moderate. Levomilnacipran and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SNRIs reduce platelet serotonin uptake and impair platelet aggregation, and NSAIDs add antiplatelet effects and gastric mucosal injury. The combination raises the risk of bleeding, notably upper gastrointestinal bleeding.
How serious is the interaction between Levomilnacipran and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and bruising, and consider a proton pump inhibitor in higher-risk patients. Use the lowest NSAID dose for the shortest period or choose paracetamol.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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