Drug interactions
Levomilnacipran + Meloxicam
Severity: Moderate
Levomilnacipran and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SNRIs such as levomilnacipran reduce platelet serotonin uptake and impair aggregation, and NSAIDs add antiplatelet and gastric-injury effects. Together they increase the risk of bleeding, particularly upper gastrointestinal bleeding.
What this interaction means in plain words
Levomilnacipran and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levomilnacipran belongs to Central Nervous System; Meloxicam belongs to Musculoskeletal.
Why it happens
Additive impairment of platelet function (serotonin depletion plus COX-1 inhibition) with NSAID mucosal injury.
What to do
Monitor for gastrointestinal bleeding and bruising, and consider gastroprotection such as a proton pump inhibitor in higher-risk patients. Prefer paracetamol where suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Meloxicam?
MediHelp rates the interaction as moderate. Levomilnacipran and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SNRIs such as levomilnacipran reduce platelet serotonin uptake and impair aggregation, and NSAIDs add antiplatelet and gastric-injury effects. Together they increase the risk of bleeding, particularly upper gastrointestinal bleeding.
How serious is the interaction between Levomilnacipran and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal bleeding and bruising, and consider gastroprotection such as a proton pump inhibitor in higher-risk patients. Prefer paracetamol where suitable.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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